TRI-EST contains estriol 80% estradiol 10% estrone 10%

All topical gels are formulated using a trans-organo gel base. This base utilizes lecithin and a penetrating oil to provide better absorption. Although these gels may be applied to various sites, they are most often applied to the inside of the forearm (usually at bedtime).

There is a trade-off in using in the trans-organo gel base instead of a cosmetic type cream like Dermabase. The cosmetic creams are nice to apply, but all contain mineral oil that can reduce absorption. The gel tends to be sticky if doses are greater than ¼ tsp.; most women have no problem with this dosage size.

All gels are compounded so that ¼ tsp = 1 Gram

Some studies suggest that estriol (E3) has protective effects against breast cancer. However, this data is far from conclusive. It seems that higher circulating levels of estriol correlate with a lower incidence of breast cancer.

Several recent studies also suggest that estriol 2 mg/day produces bone-density benefits. New studies indicate, that contrary to previous thought, the long-term use of this dose will require progesterone opposition.

Estriol vaginal cream has clearly been shown to be effective in the treatment of postmenopausal uro-genital symptoms. It is widely used in Europe and offers the choice of a low potency estrogen to treat these symptoms. It does not seem to cause endometrial hyperplasia. The most commonly used dose is 0.5 mg daily for 3 weeks followed by a maintenance dose of 0.5 mg twice a week. Doses of 1 mg have also been used.

Estriol does seem to be effective for the control of the menopausal symptoms of hot flashes and sleep disturbance. Unfortunately for some women, doses of 6-8 mg are required and this often results in nausea.

BI-EST and TRI-EST are formulated in an attempt to mirror the body’s endogenously produced hormones and to combine the safety of estriol with the long-term benefits of estradiol/estrone. These formulations also seem to be an alternative for patients who develop side effects such as bloating, nausea, and breast tenderness from equine estrogens. Many physicians feel that BI-EST or TRI-EST 2.5 mg are equivalent to 0.625 mg conjugated estrogens.